Use and method of application Group 1 was treated orally with 15 drops, 3 times a day for 5 months with the homeopathic solution of 21st Century HGH potentized to 30X, which was bottled in 30m1 amber bottles. Group 2 was treated with 21st Century HGH in the same manner as Group 1 but, in addition, were treated with the homeopathic foumulation of HE potentized to 3X in quantities of 15 drops, 3 times a day orally, during 5 months. Group 3, which served as the control group, was treated with a placebo, administered orally in quantities of 15 drops 3 times a day during 5 months. Results All groups showed a statistically significant increase in plasmatic levels of IGF-I, although the percentage increase of said hormone was greatest in Group 1 (p < 0.001). Blood glucose showed a statistically significant increase in the group treated with only 21st Century HGH (p < 0.05). IgG decreased in Group 1 (p < 0.01) and in Group 2 (p < 0.02). Patients' weight and excess body fat (measured as the corporal fat level in excess of predicted normal prophylactic ranges for each participant given their sex, age and height) decreased more in groups 1 and 2 (p < 0.001 and p < 0.01). Discussion Currently, modifications that occur with aging in the growth hormone axis (hypothalamus-hypophysis-liver) are well known. The decrease in the production of GH by the anterior hypophysis, stands out, as well as the production of Somatomedin-C (IGF-I), by GH stimulus in the liver. On the other hand, studies which have used human recombinant GH or GHRH in the elderly have shown that this produces an increase in plasmatic levels of Somatomedin-C and glycemia during fasting.  The results that we obtained with the use of the homeopathic formulation of GH indicated that the 2 groups that used said preparation, showed an average percentage increase up to 130 (P < 0.001) in plasma levels of IGF-I, and in some cases up to 160 if we take into consideration the average plus a standard error to the right. These increases of IGF-I are the firmest bases we have to affirm that the homeopathic formulation of GH exercises its action at least at the liver level; we do not believe that said formulation will act at the hypothalmic level by increasing the quantities of GHRH or by inhibiting the somatostatin (SRIF). continued part 3